APE1/Ref-1 overview

Apurinic apyrimidinic endonuclease 1/Redox factor-1 (APE1/Ref-1) is a multifunctional protein; its N-terminal region is involved in redox activity and regulates multiple transcription factors, and its C-terminus is involved in base excision DNA repair activity. APE1/Ref-1 is mainly localized in the nucleus and shows dynamic shuttling between the nucleus and cytoplasm in response to various stress stimuli. Recently, it have a reported the possibility for the extracellular secretion of APE1/Ref-1. Elevated level of APE1/Ref-1 were observed in the blood of endotoxemic rats, and in bladder cancer.

APE1/Ref-1 protein, Human, Recombinant (His Tag) (MR-RPAPE-*** )

Protein information Data sheet

Protein Gene name APEX1
Other name APE1, Ref-1, APE1/Ref-1
NCBI Reference Sequence NM_001641.3
Cat.No MR-RPAPE-***
Size 0.05, 0.1, 0.5, 1 mg/ml
Host E. Coli
Form/ storage solution Solution, containing 10mM Tris-HClpH8, 50mM Nacl, 1mM DTT, 0.05mM EDTA, 200 µg/ml BSA, 50% glycerol
Concentration 1mg/ml
Protein Form Full Length, Recombinant
Protein Tag or Fusion N-terminal His tag
Protein size 39 kDa
Purity ≥ 95% by SDS-PAGE
Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles
Protein Host Protein Tag or Fusion Endotoxin Size Cat No. Price(₩)
(VAT 별도)
Standard protein For APE1/Ref-1 ELISA E.coli His - 0.01㎎ MR-RPAPE-001 ₩120,000 Inquiry
APE1/Ref-1 protein, Human, Recombinant E.coli His - 0.1㎎ MR-RPAPE-010 ₩450,000 Inquiry
APE1/Ref-1 protein, Human, Recombinant E.coli His <1EU/㎍ 0.1㎎ MR-EAPE-100 ₩612,000 Inquiry
Recombinant APE1/Ref-1 Fc Fusion protein E.coli His <1EU/㎍ 0.1㎎ MR-EFAPE-100 ₩660,000 Inquiry


  • Robson, C.N. and Hickson, D.I. (1991) Nucleic Acids Res. 19, 5519–5523.
  • Demple, B. et al. (1991) Proc. Natl. Acad. Sci. USA 88, 11450–11454.
  • Park, M. et al, (2016) Sci Reports 6:23015.