ANTIBODY MediRedox
APE1/Ref-1 overview
Apurinic apyrimidinic endonuclease 1/Redox factor-1 (APE1/Ref-1) is a multifunctional protein; its N-terminal region is involved in redox activity and regulates multiple transcription factors, and its C-terminus is involved in base excision DNA repair activity. APE1/Ref-1 is mainly localized in the nucleus and shows dynamic shuttling between the nucleus and cytoplasm in response to various stress stimuli. Recently, it have a reported the possibility for the extracellular secretion of APE1/Ref-1. Elevated level of APE1/Ref-1 were observed in the blood of endotoxemic rats, and in bladder cancer.
APE1/Ref-1 monoclonal antibody (clone 14E1) Data sheet
| Protein name | APE1/Ref-1, APEX1, APE1, Ref-1 |
|---|---|
| Cat.No | MR-MA14 |
| clone | 14E1 |
| Species reactivity | Human, mouse, Rat |
| Size | 100µg |
| Concentration | 1mg/ml |
| host | Mouse |
| Immunogen | Full-length, Recombinant human APE1/Ref-1 protein |
| Conjugate | Unconjugated |
| Form/ storage solution | Liquid, 0.05% sodium azide in PBS |
| Molecular weight | 36.5 kDa |
| Purification | IgG purified |
| Storage | Shipped at 4°C. Upon delivery aliquot and store at -20°C Avoid repeated freeze / thaw cycles |
| Applications | Western blot (WB) IHC-P |
| Price |
￦540,000 (VAT excluded) |
| ETC | Inquiry |
APE1/Ref-1 in Human colon tissue. APE1/Ref-1 was detected in a PFA fixed paraffin-embedded section of human colon tissue using an APE1/Ref-1 monoclonal antibody (14E1).
Detection of mouse APE1/Ref-1 by western blotting. Western blot showing lysates of mouse tissue (Liver and Kidney). The APE1/Ref-1 band with approximately 36.5kDa was detected.
